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What is acute toxicology and why is it important in drug development?

Acute toxicology describes the adverse effects of a substance that result from a single dose or multiple doses administered in close succession. The adverse events occur within a short time after the substance is administered. Acute toxicology is used to determine the pharmacological effects of different doses, including the lethal dose, and produces a description of the effects resulting from a single or repeated exposure. This data helps predict the safety of the compound in humans helps guide the dosing in clinical studies. To learn more about acute toxicology and why it is important for drug development, click on the links below.

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Partnership Opportunities

• Therapies for Rare and Neglected Diseases, NIH: About the TRND Program
• Therapies for Rare and Neglected Diseases, NIH: Apply to TRND

FDA Guidance

• FDA: Guidance for Industry – Single Dose Acute Toxicology Testing for Pharmaceuticals

Databases

• NCRR: National Gene Vector Biorepository Toxicology Database