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What is PK (ADME) and is it important in drug development?

Pharmacokinetics (PK) is the study of how the body metabolizes a drug and how this drug is distributed throughout the body. PK (ADME) refers to pharmacokinetic (PK) studies that quantitatively measure the absorption, distribution, metabolism and elimination (ADME) of a compound in a living organism. To learn more about PK (ADME) and why it is important for drug development, click on the links below.

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Relevant publications

• Eddershaw et al.: ADME/PK as Part of A Rational Approach to Drug Discovery
• Ekins et al.: Progress in Predicting Human ADME Parameters In Silico
• Wishart: Improving Early Drug Discovery through ADME Modeling: An Overview
• Emoto et al.: Methodologies for Investigating Drug Metabolism at the Early Drug Discovery Stage

Related Tools

FDA Guidance

• FDA: Guidance for Industry – Drug Metabolism / Drug Interaction Studies in the Drug Development Process: Studies In Vitro
• FDA: Guidance for Industry – Nonclinical Safety Studies for the Conduct of Human Clinical Trials for Pharmaceuticals

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