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What are phenotypes and why are they important in drug development?

An individual’s phenotype refers to their observable traits, such as one’s height or eye color. This is the physical expression of an individual’s genes (genotype). In addition to genetic factors, a person’s phenotype is also influenced by environmental factors. To learn more about phenotypes and why they are important for drug development, click on the links below.

• Genetic Alliance: WikiGenetics – Genes and Their Properties
• Genetic Alliance: WikiGenetics
• Genetic Alliance: Submitting Information About Variation to Public Databases: An NCBI Perspective

Testimonials: How we did it

Relevant publications

• Sage Bionetworks: Genetics of Gene Expression and Its Effects on Disease
• Sage Bionetworks: An Integrative Genomics Approach to Infer Casual Associations between Gene Expression and Disease
• Sage Bionetworks: Variations in DNA Elucidate Molecular Networks that Cause Disease
• Sage Bionetworks: Integrating Pathway Analysis and Genetics of Gene Expression for Genome-Wide Association Studies

Related Tools

Repositories with Genotype — Phenotype Datasets

• NIH, NHGRI: The Cancer Genome Atlas Data Portal
• NCBI: dbGaP
• University of Tokyo and Japan Science and Technology Agency: Japanese SNP Database

Repositories with Genotype — Phenotype Datasets and Samples

• NIDDK: Data, Biosample, and Genetics Repository
• NHBLI: Biological Specimen and Data Repository Coordinating Center
• The Jackson Laboratory: Mouse Genome Informatics