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What are genotypes and why are they important in drug development?

Genotypes are an individual’s genetic makeup. Every person has two different copies of each gene (alleles) inherited from their parents. The expression of an individual’s genotype determines their phenotype (observable traits). To learn more about genotypes and why they are important for drug development, click on the links below.

• Genetic Alliance: WikiGenetics – Genes and Their Properties
• Genetic Alliance: WikiGenetics
• Genetic Alliance: Submitting Information About Variation to Public Databases: An NCBI Perspective

Testimonials: How we did it

Relevant publications

• Sage Bionetworks: Genetics of Gene Expression and Its Effects on Disease
• Sage Bionetworks: An Integrative Genomics Approach to Infer Casual Associations between Gene Expression and Disease
• Sage Bionetworks: Variations in DNA Elucidate Molecular Networks that Cause Disease
• Sage Bionetworks: Integrating Pathway Analysis and Genetics of Gene Expression for Genome-Wide Association Studies

Related Tools

Repositories with Genotype Datasets

• NIH, NHGRI: The Cancer Genome Atlas Data Portal
• NCBI: dbGaP
• NCBI: The International HapMap
• NCBI: dbSNP
• University of Tokyo and Japan Science and Technology Agency: Japanese SNP Database

Repositories with Genotype Datasets and Samples

• NIDDK: Data, Biosample, and Genetics Repository
• NHBLI: Biological Specimen and Data Repository Coordinating Center
• The Jackson Laboratory: Mouse Genome Informatics

Genotyping Tools and Services

• Center for Inherited Disease Research, Johns Hopkins University: Sequencing and Genotyping Services